Platelet-derived growth factor receptor alpha (pdgfr-α) gene in zebrafish embryonic development
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چکیده
منابع مشابه
Platelet-derived growth factor receptor alpha (pdgfr-α) gene in zebrafish embryonic development
Here we present the cloning of a full-length zebrafish pdgfr-a cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-a mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression of the gene started after the onset of segmentation and is mainly localized i...
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BACKGROUND Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused developmental defects of multiple endoderm and mesoderm derived structures, resulting in a complex phenotypes including orofacial cleft, spi...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2002
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(02)00142-9